![]() Fixes a bug that caused PDF or EPS slice exports to include all content outside the slice and increase the size of the final export.Fixes a bug that stopped the Workspace window from showing local templates if you were using a license and not signed into a Workspace.Bug and crash fixes This release fixes some bugs and crashes that you’ve reported in our latest update.An updated paper will be made available soon. Read the bioRxiv preprint from April 2021.Watch a walkthrough video covering how to using the new algorithm in CryoSPARC.Read an in-depth guide, including new example results using 3DFlex. ![]() ![]() 3DFlex requires tuning of some parameters and optionally can take custom inputs defining geometry and topology of the target molecule.Given a latent position, the flow generator outputs a 3D deformation field mapping the canonical density to a particular conformation 3DFlex jointly learns a single canonical 3D density map of the particle, latent coordinates for each particle image, and a flow generator network.It can model non-rigid motion and flexibility of a protein molecule across its conformational landscape, and can use the motion model to combine signal from particle images in different conformations to improve refinement resolution in flexible regions. 3D Flexible Refinement (3DFlex) ( Beta) is a motion-based deep generative model for continuous heterogeneity.
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